DNA Polymerase - Variation Across Species - Eukaryotic DNA Polymerase - Reverse Transcriptase

Reverse Transcriptase

Some viruses also encode special DNA polymerases, such as Hepatitis B virus DNA polymerase. These may selectively replicate viral DNA through a variety of mechanisms. Retroviruses encode an unusual DNA polymerase called reverse transcriptase, which is an RNA-dependent DNA polymerase (RdDp). It polymerizes DNA from a template of RNA. The reverse transcriptase family contains examples from both retroviruses and eukaryotic polymerases. The eukaryotic polymerases are usually restricted to telomerases. These polymerases use an RNA template to synthesize the DNA strand.


DNA polymerase family A
c:o6-methyl-guanine pair in the polymerase-2 basepair position
Identifiers
Symbol DNA_pol_A
Pfam PF00476
InterPro IPR001098
PROSITE PDOC00412
SCOP 1dpi
SUPERFAMILY 1dpi
Available protein structures:
Pfam structures
PDB RCSB PDB; PDBe
PDBsum structure summary
DNA polymerase family B
crystal structure of rb69 gp43 in complex with dna containing thymine glycol
Identifiers
Symbol DNA_pol_B
Pfam PF00136
Pfam clan CL0194
InterPro IPR006134
PROSITE PDOC00107
SCOP 1noy
SUPERFAMILY 1noy
Available protein structures:
Pfam structures
PDB RCSB PDB; PDBe
PDBsum structure summary
DNA polymerase type B, organellar and viral
phi29 dna polymerase, orthorhombic crystal form, ssdna complex
Identifiers
Symbol DNA_pol_B_2
Pfam PF03175
Pfam clan CL0194
InterPro IPR004868
Available protein structures:
Pfam structures
PDB RCSB PDB; PDBe
PDBsum structure summary

Read more about this topic:  DNA Polymerase, Variation Across Species, Eukaryotic DNA Polymerase

Other articles related to "reverse transcriptase, reverse transcriptases, reverse":

Retron Msr RNA
... Synthesis of DNA by a retron-encoded reverse transcriptase (RT) results in a DNA-RNA chimera which is composed of small single-stranded DNA linked to small single-stranded RNA ... is encoded by the msr gene, while the product of the ret gene is a reverse transcriptase similar to the RTs produced by retroviruses and other types of retroelements ... Like other reverse transcriptases, the retron RT contains seven regions of conserved amino acids (labeled 1-7 in the figure), including a highly conserved tyr-ala-asp-asp (YAD ...
Ann Kiessling - Career
... Kiessling is noted for her discovery of reverse transcriptase activity in normal human cells (Kiessling Goulian) ... Prior to this discovery, it had been assumed that reverse transcriptase was an enzyme found only in retroviruses(such as HIV) ... To understand the normal biologic role of reverse transcriptase, Kiessling began to study eggs and early cleaving embryos ...
Reverse Transcriptase - Applications - Molecular Biology
... For more details on this topic, see Reverse transcription polymerase chain reaction ... Reverse transcriptase is commonly used in research to apply the polymerase chain reaction technique to RNA in a technique called reverse transcription polymerase chain reaction (RT-PCR) ... can be applied only to DNA strands, but, with the help of reverse transcriptase, RNA can be transcribed into DNA, thus making PCR analysis of RNA molecules possible ...
Dulbecco - Scientific Career - Nobel Prize
... of viral genes to the cell is mediated by an enzyme called reverse transcriptase (or, more precisely, RNA-dependent DNA polymerase), which replicates the viral ... In addition, it is well-known that in the 1980s and 1990s, an understanding of reverse transcriptase and of the origins, nature, and properties of human immunodeficiency virus (HIV, of ...

Famous quotes containing the word reverse:

    They shall beat their swords into plowshares, and their spears into pruninghooks: nation shall not lift up sword against nation, neither shall they learn war any more.
    Bible: Hebrew Isaiah, 2:4.

    The words reappear in Micah 4:3, and the reverse injunction is made in Joel 3:10 (”Beat your plowshares into swords ...”)