DNA Damage Theory of Aging - Conclusions

Conclusions

Numerous studies have shown that DNA damage accumulates in brain, muscle, liver, kidney, and in long-lived stem cell. These accumulated DNA damages are the likely cause of the decline in gene expression and loss of functional capacity observed with increasing age. On the other hand, accumulation of mutations, as distinct from DNA damages, is not a plausible candidate as the primary cause of aging. A calorie-restricted diet in mammals improves lifespan, and this improvement is associated with a decrease in oxidative DNA damage. Several inherited genetic defects in ability to repair DNA damage give rise to premature aging suggesting a causal relationship between DNA damage and aging. In comparisons of different mammalian species that differ in lifespan, DNA repair capacity is found to correlate with lifespan. The principal source of the DNA damages leading to normal aging appears to be reactive oxygen species, produced as byproducts of normal cellular metabolism.

Read more about this topic:  DNA Damage Theory Of Aging

Other articles related to "conclusions":

Mitchell Report - Report Conclusions
... will look past the players' names that are included in the report and focus on the conclusions he reached during his investigation ... Mitchell presents his conclusions in five sections ...
Bélmez Faces - The Investigations - The Forgery Hypothesis - Conclusions
... Another explanation might be the use of agents sensitive to light (which was not mentioned in either Jordán or Perera's repertoire of forgery hypotheses) silver nitrate which, when subjected to ultraviolet sunlight, darkens ... In general, there may be at least three chemical sources capable of producing an effect similar to that of the Bélmez faces (1) Products that affect the chemical structure of the cement which include some oxidizing agents and several acids (all types of cement are of alkaline nature and therefore easily attacked by acids) (2) products that leave the cement intact but change their chemical structure upon contact with external agents such as light or chemical reagents and (3) the utilization of a pigment in a vehicle or resin, as discussed by Ruiz-Noguez in his commentary on the ICV chart. ...
Columbia School Of Linguistics - Orientations
... Conclusions about how the mind functions, based the structure of language, should wait until a new, more reliable linguistics emerges, as did astronomy from its origins in astrology ... a kind of logic or mathematics, CSL uses mathematics as a tool to analyze and draw conclusions about languages ... compare numbers of occurrences of various phenomena and then apply statistical criteria to draw conclusions about the reasons for this usage ...
Symphonies By Pyotr Ilyich Tchaikovsky - Conclusions
... However, Cooper suggests, if they were to be "judged as a hybrid species" of symphony and symphonic poem, with inner workings more flexible and varied than sonata form might allow inhabiting the general four–movement structure to accommodate the musical and extra–musical demands sought not just by Tchaikovsky but also a number of other Romantic–age composers, they could be considered "completely successful." This, again in architectural terms, would be like when Gothic style was combined with the ideals of the Renaissance and the Counter-Reformation and a genuinely new style, the Baroque, resulted, "an organic development from the Gothic but as different in individuality as a child from its father." Soviet musicologist Boris Asafyev, in fact, calls the Tchaikovsky symphonies "dramatic" as opposed to the "non–dramatic" symphonies of Franz Schubert and Alexander Glazunov, as though he is discussing, if not two entirely different genres, then two separate variations on a common form ... Brown delineates the issue along cultural as well as formal lines ...
Byron Review - Reception of The Review - UK Newspaper Reporting
... way in which the stories were phrased, and in particular the conclusions drawn by the newspapers, were almost entirely at odds with the actual ... space to demonising videogames, again reporting contrary to the conclusions drawn in the review ...

Famous quotes containing the word conclusions:

    In the dime stores and bus stations,
    People talk of situations,
    Read books, repeat quotations,
    Draw conclusions on the wall.
    Bob Dylan [Robert Allen Zimmerman] (b. 1941)

    I have always been, am, and propose to remain a mere scholar. All that I have ever proposed to myself is to say, this and this I have learned; thus and thus have I learned it; go thou and learn better; but do not thrust on my shoulders the responsibility for your own laziness if you elect to take, on my authority, conclusions the value of which you ought to have tested for yourself.
    Thomas Henry Huxley (1825–95)

    Now, were I once at home, and in good satire,
    I’d try conclusions with those Janizaries,
    And show them what an intellectual war is.
    George Gordon Noel Byron (1788–1824)