DNA Damage

Some articles on dna, dna damage:

Wee1 - Role in Cancer
... The mitosis promoting factor MPF also regulates DNA-damage induced apoptosis ... by WEE1 causes aberrant mitosis and thus resistance to DNA-damage induced apoptosis ... factor 2 (KLF2) negatively regulates human WEE1, thus increasing sensitivity to DNA-damage induced apoptosis in cancer cells ...
Cyclin D - Regulation - Regulation in Humans
... There are two ways in which DNA damage affects Cdks ... Following DNA damage, cyclin D (cyclin D1) is rapidly and transiently degraded by the proteasome ... Another way in which DNA damage targets Cdks is p53-dependent induction of p21, which inhibits cyclin E-Cdk2 complex ...
Transcription-coupled Repair - Nucleotide Excision Repair in Eukaryotes - Dual Incision
... TFIIH and XPG are first recruited to the site of DNA damage (XPG stabilizes TFIIH) ... subunits of XPD and XPB act as a helicase and ATPase respectively - they help unwind DNA and generate a junction between the double-stranded and single-stran ... In addition to stabilizing TFIIH, XPG also has endonuclease activity it cuts DNA damage on the 3' side while the XPF-ERCC1 heterodimeric protein cuts on the 5' side ...
Pancratistatin - Biological Activity
... Pancratistatin does not cause DNA double-strand breaks or DNA damage prior to the execution phase of apoptosis in cancer cells ... treatment, indicated that VP-16 causes substantial DNA damage in normal non-cancerous blood cells, while Pancratistatin does not cause any DNA double-strand breaks or DNA damage in non-ca ... Since Pancratistatin shows little structural similarity to any DNA intercalating drug or to paclitaxel derivatives, it appears to be non-genotoxic ...
CHEK1
... cytosol Biological process • cell cycle checkpoint • DNA damage checkpoint • G2/M transition of mitotic cell cycle • DNA replication • DNA repair ...

Famous quotes containing the words damage and/or dna:

    “I came to explore the wreck.
    The words are purposes.
    The words are maps.
    I came to see the damage that was done
    and the treasures that prevail.”
    —Adrienne Rich (b. 1929)

    “Here [in London, history] ... seemed the very fabric of things, as if the city were a single growth of stone and brick, uncounted strata of message and meaning, age upon age, generated over the centuries to the dictates of some now all-but-unreadable DNA of commerce and empire.”
    —William Gibson (b. 1948)