DNA-PKcs - Function

Function

DNA-PKcs is the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase called DNA-PK. The second component is the autoimmune antigen Ku. On its own, DNA-PKcs is inactive and relies on Ku to direct it to DNA ends and trigger its kinase activity DNA-PKcs is required for the non-homologous end joining (NHEJ) pathway of DNA repair, which rejoins double-strand breaks. It is also required for V(D)J recombination, a process that utilizes NHEJ to promote immune system diversity. DNA-PKcs knockout mice have severe combined immunodeficiency due to their V(D)J recombination defect.

Many proteins have been identified as substrates for the kinase activity of DNA-PK. Autophosphorylation of DNA-PKcs appears to play a key role in NHEJ and is thought to induce a conformational change that allows end processing enzymes to access the ends of the double-strand break. DNA-PK also cooperates with ATR and ATM to phosphorylate proteins involved in the DNA damage checkpoint.

Read more about this topic:  DNA-PKcs

Other articles related to "function":

Integral - Fundamental Theorem of Calculus - Statements of Theorems
... Let f be a continuous real-valued function defined on a closed interval ... Let F be the function defined, for all x in, by Then, F is continuous on, differentiable on the open interval (a, b), and for all x in (a, b) ... Let f be a real-valued function defined on a closed interval that admits an antiderivative g on ...
Integral - Fundamental Theorem of Calculus
... the statement that differentiation and integration are inverse operations if a continuous function is first integrated and then differentiated, the original function is retrieved ... compute integrals by using an antiderivative of the function to be integrated ...
Integral - Extensions - Multiple Integration
... In general, an integral over a set E of a function f is written Here x need not be a real number, but can be another suitable quantity, for instance, a vector in R3 ... Just as the definite integral of a positive function of one variable represents the area of the region between the graph of the function and the x-axis, the ... the triple integral — the integral of a function in three variables — of the constant function f(x, y, z) = 1 over the above mentioned region between the surface and the ...

Famous quotes containing the word function:

    My function in life is not to be a politician in Parliament: it is to get something done.
    Bernadette Devlin (b. 1947)

    The function of the actor is to make the audience imagine for the moment that real things are happening to real people.
    George Bernard Shaw (1856–1950)

    For me being a poet is a job rather than an activity. I feel I have a function in society, neither more nor less meaningful than any other simple job. I feel it is part of my work to make poetry more accessible to people who have had their rights withdrawn from them.
    Jeni Couzyn (b. 1942)