DNA-binding proteins are proteins that are composed of DNA-binding domains and thus have a specific or general affinity for either single or double stranded DNA. Sequence-specific DNA-binding proteins generally interact with the major groove of B-DNA, because it exposes more functional groups that identify a base pair. However there are some known minor groove DNA-binding ligands such as Netropsin, Distamycin, Hoechst 33258, Pentamidine and others.
Other articles related to "proteins, protein":
... In contrast, other proteins have evolved to bind to particular DNA sequences ... various transcription factors, which are proteins that regulate transcription ... for transcription, either directly or through other mediator proteins this locates the polymerase at the promoter and allows it to begin transcription ...
... Further information DNA-binding protein Structural proteins that bind DNA are well-understood examples of non-specific DNA-protein interactions ... Within chromosomes, DNA is held in complexes with structural proteins ... These proteins organize the DNA into a compact structure called chromatin ...
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“Civilization means food and literature all round. Beefsteaks and fiction magazines for all. First-class proteins for the body, fourth-class love-stories for the spirit.”
—Aldous Huxley (18941963)