Identifiers Symbols DLG1; DLGH1; SAP-97; SAP97; dJ1061C18.1.1; hdlg External IDs OMIM: 601014 MGI: 107231 HomoloGene: 20869 GeneCards: DLG1 Gene

Gene Ontology
Molecular function guanylate kinase activity
phosphoprotein phosphatase activity
protein binding
protein C-terminus binding
cytoskeletal protein binding
potassium channel regulator activity
protein kinase binding
phosphatase binding
mitogen-activated protein kinase kinase binding
protein complex scaffold
ion channel binding
L27 domain binding
Cellular component immunological synapse
endoplasmic reticulum
endoplasmic reticulum membrane
Golgi apparatus
plasma membrane
cell-cell junction
tight junction
internal side of plasma membrane
postsynaptic density
basolateral plasma membrane
lateral plasma membrane
cell junction
cell projection membrane
neuromuscular junction
node of Ranvier
myelin sheath abaxonal region
lateral loop
membrane raft
postsynaptic membrane
perinuclear region of cytoplasm
MPP7-DLG1-LIN7 complex
Biological process branching involved in ureteric bud morphogenesis
immunological synapse formation
endothelial cell proliferation
lens development in camera-type eye
T cell cytokine production
actin filament organization
establishment or maintenance of cell polarity
synaptic transmission
axon guidance
positive regulation of cell proliferation
cell-cell adhesion
virus-host interaction
positive regulation of actin filament polymerization
cortical actin cytoskeleton organization
mitotic cell cycle G1/S transition checkpoint
membrane raft organization
activation of protein kinase activity
T cell activation
negative regulation of T cell proliferation
regulation of membrane potential
amyloid precursor protein metabolic process
positive regulation of potassium ion transport
negative regulation of mitotic cell cycle
reproductive structure development
embryonic skeletal system morphogenesis
smooth muscle tissue development
negative regulation of epithelial cell proliferation
hard palate development
tight junction assembly
protein localization to plasma membrane
positive regulation of establishment of protein localization to plasma membrane
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 1739 13383 Ensembl ENSG00000075711 ENSMUSG00000022770 UniProt Q12959 Q811D0 RefSeq (mRNA) NM_001098424 NM_001252433 RefSeq (protein) NP_001091894 NP_001239362 Location (UCSC) Chr 3:
196.77 – 197.03 Mb Chr 16:
31.66 – 31.87 Mb PubMed search

Disks large homolog 1 (DLG1), also known as synapse-associated protein 97 or SAP97, is a protein that in humans is encoded by the SAP97 gene.

SAP97 is a mammalian MAGUK-family member protein that is similar to the Drosophila protein Dlg1 (the protein is alternatively referred to as hDlg1, and the human gene is DLG1). SAP97 is expressed throughout the body in epithelial cells. In the brain it is involved in the trafficking of ionotropic receptors from the endoplasmic Reticulum to the plasma membrane, and may be involved in the trafficking AMPAR during synaptic plasticity.

Read more about DLG1:  Function, Structure

Other articles related to "dlg1":

DLG1 - Structure
... The n-terminal of SAP97 can be alternatively spliced to contain a double-cysteine/palmitoylation site (α-isoform), or an L27 domain (β-isoform ... The L27 domain is involved in SAP97 oligomerization with other SAP97 molecules, CASK, and other L27-domain-containing proteins ...