Disulphiram

Disulphiram

Disulfiram is a drug discovered in the 1920s and used to support the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. It blocks the processing of alcohol in the body by inhibiting acetaldehyde dehydrogenase thus causing an unpleasant reaction when alcohol is consumed. Disulfiram should be used in conjunction with counseling and support. Trade names for disulfiram in different countries are Antabuse and Antabus manufactured by Odyssey Pharmaceuticals. Disulfiram is also being studied as a treatment for cocaine dependence, as it prevents the breakdown of dopamine (a neurotransmitter whose release is stimulated by cocaine); the excess dopamine results in increased anxiety, higher blood pressure, restlessness and other unpleasant symptoms. Several studies have reported that it has anti-protozoal activity as well. Disulfiram is the subject of research for use in cancer therapy and as a treatment in HIV cure research (to activate the reservoir of HIV infected resting CD4 cells).

Read more about Disulphiram:  History, Side Effects, Dosage, Preparation, Similarly Acting Substances

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