Designer Baby - Future Technology - Homologous Recombination

Homologous Recombination

One of the more promising techniques of proper gene insertion is homologous recombination. This process of identifying, cutting out, and replacing a misspelled sequence of DNA letters occurs naturally in the cell. Scientists could later turn predesigned, implanted chromosomes off by activating a recombinase that would recombine the ends of the chromosomes. While homologous recombination avoids the problem of insertional mutagenesis, it is very inefficient, producing only about one out of a million cells that have actually taken up the new gene sequence.

Read more about this topic:  Designer Baby, Future Technology

Other articles related to "homologous, homologous recombination":

DNA Repair Mechanisms - Double-strand Breaks
... to repair double-strand breaks (DSBs) non-homologous end joining (NHEJ), microhomology-mediated end joining (MMEJ), and homologous recombination ... To guide accurate repair, NHEJ relies on short homologous sequences called microhomologies present on the single-stranded tails of the DNA ends to be joined ... the cell has replicated its DNA, since there is no template available for repair by homologous recombination ...
Homologous Recombination - Technological Applications - Cancer Therapy
... with BRCA mutations have deficiencies in homologous recombination, and drugs to exploit those deficiencies have been developed and used successfully in clinical trials ... BRCA1 and BRCA2 are necessary for DNA repair by homologous recombination ... called base-excision repair usually compensates for the lack of DNA repair by homologous recombination ...