Contiguous Gene Syndrome

A contiguous gene syndrome is a syndrome caused by abnormalities of 2 or more genes that are located next to each other on a chromosome. Prader-Willi Syndrome, which is caused by the microdeletion of 15q11-13, is a common example. Prader-Willi syndrome occurs when the deletion occurs on the paternal chromosome. If this deletion occurs on the maternal chromosome, it causes the Angelman syndrome. DiGeorge syndrome(deletion of 22q11.2) is a particularly well known example. WAGR syndrome (deletions of 11p13) is another example.

Famous quotes containing the words syndrome and/or contiguous:

    [T]he syndrome known as life is too diffuse to admit of palliation. For every symptom that is eased, another is made worse. The horse leech’s daughter is a closed system. Her quantum of wantum cannot vary.
    Samuel Beckett (1906–1989)

    Now in contiguous drops the flood comes down,
    Threat’ning with deluge this devoted town.
    To shops in crowds the daggled females fly,
    Pretend to cheapen goods, but nothing buy.
    Jonathan Swift (1667–1745)