A contiguous gene syndrome is a syndrome caused by abnormalities of 2 or more genes that are located next to each other on a chromosome. Prader-Willi Syndrome, which is caused by the microdeletion of 15q11-13, is a common example. Prader-Willi syndrome occurs when the deletion occurs on the paternal chromosome. If this deletion occurs on the maternal chromosome, it causes the Angelman syndrome. DiGeorge syndrome(deletion of 22q11.2) is a particularly well known example. WAGR syndrome (deletions of 11p13) is another example.
Famous quotes containing the words syndrome and/or contiguous:
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—Samuel Beckett (19061989)
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