Conditioned Place Preference - Pharmacological Effects - Dopaminergic Drugs - Methylphenidate

Methylphenidate

Methylphenidate, or as it's more commonly known as Ritalin is a psychomotor stimulant that blocks the dopamine and norepinephrine transporter. By blocking the dopamine and norepinephrine transporter, the reuptake of dopamine and norepinephrine cannot occur. This causes an increase of dopamine and norepinephrine in the synapse. Methylphenidate functions in a similar way to cocaine. Methylphenidate has been primarily used in the treatment of ADHD. It has demonstrated a conditioned place preference at 5 mg/kg through intravenous and intraperitoneal injections. Even though the conditioned place preference of methylphenidate appears to show it has an addictive property, it does not display the same effects in humans. Methylphenidate demonstrates an initial high, but the high drops immediately and methylphenidate has a long half life with no high associated. Taking any further doses will not bring the high back because of the long half life of the drug, unlike cocaine with a shorter half life.

Read more about this topic:  Conditioned Place Preference, Pharmacological Effects, Dopaminergic Drugs

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