Complement Deficiency

Complement deficiency is an immunodeficiency of absent or suboptimal functioning of one of the complement system proteins.

The disorders can be divided into two categories:

  • Disorders of the proteins that act to inhibit the complement system (such as C1-inhibitor) can lead to an overactive response, causing conditions such as hereditary angioedema and hemolytic-uremic syndrome.
  • Disorders of the proteins that act to activate the complement system (such as C3) can lead to an underactive response, causing greater susceptibility to infections.

Because there are redundancies in the immune system, many complement disorders are never diagnosed. A recent study estimated that less than 10% are identified.

Read more about Complement Deficiency:  Hypocomplementemia

Other articles related to "complement deficiency, complement, deficiency":

Complement Deficiency - Hypocomplementemia
... Hypocomplementemia may be used more generally to refer to decreased complement levels while secondary complement disorder is to low complement levels that are not ...
Hyper-Ig M Syndrome Type 3
... Immune disorders Lymphoid and complement immunodeficiency (D80–D85, 279.0–4) Primary Antibody/humoral (B) Hypogammaglobulinemia X-linked agammaglobulinemia Transient ...
Hyper-Ig M Syndrome Type 1 - Treatment
... OMIM 308230 Immune disorders Lymphoid and complement immunodeficiency (D80–D85, 279.0–4) Primary Antibody/humoral (B) Hypogammaglobulinemia X-linke ...
Complement 2 Deficiency
... Complement 2 deficiency is a type of complement deficiency caused by any one of several different alterations in the structure of complement component 2 ...

Famous quotes containing the words deficiency and/or complement:

    Shakespeare’s fault is not the greatest into which a poet may fall. It merely indicates a deficiency of taste.
    Denis Diderot (1713–1784)

    A healthy man, indeed, is the complement of the seasons, and in winter, summer is in his heart.
    Henry David Thoreau (1817–1862)