Collecting Duct System - Cell Types - Intercalated Cells

Intercalated Cells

Intercalated cells come in α and β varieties and participate in acid-base homeostasis.

Type of cell Secretes Reabsorbs
α-intercalated cells acid (via an apical H+-ATPase and H+/K+ exchanger) in the form of hydrogen ions bicarbonate (via band 3, a basolateral Cl-/HCO3- exchanger)
β-intercalated cells bicarbonate (via pendrin a specialised apical Cl-/HCO3-) acid (via a basal H+-ATPase)

For their contribution to acid-base homeostasis, the intercalated cells play important roles in the kidney's response to acidosis and alkalosis. Damage to the α-intercalated cell's ability to secrete acid can result in distal renal tubular acidosis (RTA type I, classical RTA).

Read more about this topic:  Collecting Duct System, Cell Types

Famous quotes containing the word cells:

    Madness is locked beneath. It goes into tissues, is swallowed by the cells. The cells go mad. Cancer is their flag. Cancer is the growth of madness denied.
    Norman Mailer (b. 1923)