**Function**

This gene encodes the alpha 3 chain, one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The alpha 3 chain of type VI collagen is much larger than the alpha 1 and 2 chains. This difference in size is largely due to an increase in the number of subdomains, similar to von Willebrand Factor type A domains, found in the amino terminal globular domain of all the alpha chains. These domains have been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. Mutations in the type VI collagen genes are associated with Bethlem myopathy. In addition to the full length transcript, four transcript variants have been identified that encode proteins with N-terminal globular domains of varying sizes.

Read more about this topic: COL6A3

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### Famous quotes containing the word function:

“The more books we read, the clearer it becomes that the true *function* of a writer is to produce a masterpiece and that no other task is of any consequence.”

—Cyril Connolly (1903–1974)

“Advocating the mere tolerance of difference between women is the grossest reformism. It is a total denial of the creative *function* of difference in our lives. Difference must be not merely tolerated, but seen as a fund of necessary polarities between which our creativity can spark like a dialectic.”

—Audre Lorde (1934–1992)

“The intension of a proposition comprises whatever the proposition entails: and it includes nothing else.... The connotation or intension of a *function* comprises all that attribution of this predicate to anything entails as also predicable to that thing.”

—Clarence Lewis (1883–1964)