Cohn Process

The Cohn process, developed by Edwin Joseph Cohn, is a series of purification steps with the purpose of extracting albumin from blood plasma. The process is based on the differential solubility of albumin and other plasma proteins based on pH, ethanol concentration, temperature, ionic strength, and protein concentration. Albumin has the highest solubility and lowest isoelectric point of all the major plasma proteins. This makes it the final production to be precipitated, or separated from its solution in a solid form. Albumin was an excellent substitute for human plasma in World War Two. When administered to wounded soldiers or other patients with blood loss, it helped expand the volume of blood and led to speedier recovery. Cohn's method was gentle enough so the protein retained its biological activity.

Read more about Cohn ProcessProcess Details, Products Other Than Albumin, Process Variations, Influences of Cohn Process

Other articles related to "cohn, cohn process, process":

Blood Plasma Fractionation - Plasma Processing
... Cohn during World War II ... It is known as the Cohn process (or Cohn method) ... This process is also known as cold ethanol fractionation as it involves gradually increasing the concentration of ethanol in the solution at 5oC and 3oC ...
Influences of Cohn Process
... The Cohn process was a major development in the field of blood fractionation ... The Cohn Process has been modified over the years as seen above ... In general, the Cohn Process and its variations have given a huge boost to and serve as a foundation for the fractionation industry to this day ...

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