Cohesin - Evolution

Evolution

Cohesin structure and function has been conserved in evolution. The SMC proteins are found in prokaryotes and have been conserved through evolution. The coiled coils of SMC1 and SMC3 are conserved with an amino acid divergence of less than 0.5%.

Name Saccharomyces cerevisiae Schizosaccharomyces pombe Drosophila Vertebrates
Smc1 Smc1 Psm1 DmSmc1 Smc1
Smc3 Smc3 Psm3 DmSmc3 Smc3
Scc1 Mcd1/Pds3 Rad21 DmRad21 Rad21
Scc3 Scc3 Psc3 DmSA SA1 and SA2

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