Coatlaxopeuh is a word proposed by father Mariano Jacobo Rojas of Tepoztlán as a possible Nahuatl origin of the word Guadalupe, the appellation of the Virgin of Guadalupe. The suggestion of a Nahuatl etymology for the Virgin's name was part of the Mexican indigenista debates of the mid 20th century, in which prominent intellectuals reinterpreted Mexican history with a renewed emphasis on the nation's indigenous heritage. In addition to coatlaxopeuh many other proposed Nahuatl etymologies of Guadalupe have been suggested, but in the devotional literature coatlaxopeuh remains the most accepted.

Read more about Coatlaxopeuh:  Luís Becerra Y Tanco, Indigenismo, Gloria Anzaldúa

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Coatlaxopeuh - Gloria Anzaldúa
... Gloria Anzaldúa, in her book Borderlands / La Frontera, proposes the indigenous origin of Guadalupe as Coatlalopeuh, which she translates as "She Who Has Dominion over Serpents." She argues that because Coatlalopeuh sounds like Guadalupe, the Spanish saw Coatlalopeuh as parallel or identical to "the dark Virgin, Guadalupe, patroness of West Central Spain" (Page 27) ... Anzaldúa gives Coatlaxopeuh as a variant name ...