Coagulase

Coagulase is a protein enzyme produced by several microorganisms that enables the conversion of fibrinogen to fibrin. In the laboratory, it is used to distinguish between different types of Staphylococcus isolates. Importantly, S. aureus is coagulase-positive, meaning that coagulase negativity excludes S. aureus.

It is also produced by Yersinia pestis.

Coagulase reacts with prothrombin in the blood. The resulting complex is called staphylothrombin, which enables the enzyme protease to convert fibrinogen to fibrin. This results in clotting of the blood. Coagulase is tightly bound to the surface of the bacterium S. aureus and can coat its surface with fibrin upon contact with blood. It has been proposed that fibrin-coated staphylococci resist phagocytosis, making the bacteria more virulent. Bound coagulase is part of the larger family of MSCRAMM.

Read more about CoagulaseCoagulase Test

Other articles related to "coagulase":

Staphylococcal Infection - Coagulase-negative
... epidermidis, a coagulase-negative staphylococcus species, is a commensal of the skin, but can cause severe infections in immune-suppressed patients and those with central venous catheters ... saprophyticus, another coagulase-negative species that is part of the normal vaginal flora, is predominantly implicated in genitourinary tract infections in sexually-active young women ...
Staphylococcus Lugdunensis - Description
... lugdunensis may produce a bound coagulase (that is, the enzyme is bound to the cells), a property it shares with S ... aureus, it does not produce a free coagulase ... In the laboratory, it can give a positive slide-coagulase test but a negative tube-coagulase test ...
Coagulase Test - Tube Test
... List of coagulase-positive staphylococci Staphylococcus aureus subsp ... List of coagulase-negative staphylococci of clinical significance S ...
Staphylococcal Infection - Coagulase-positive
... aureus#Role in disease The main coagulase-positive staphylococcus is Staphylococcus aureus, although not all strains of Staphylococcus aureus are coagulase positive ...
Staphylococcus Aureus - Microbiology
... aureus was differentiated from other staphylococci by the coagulase test ... aureus are coagulase positive and that incorrect species identification can impact effective treatment and control measures ... Further information Coagulase-positive staphylococcal infection ...