Click Chemistry - Applications

Applications

Click chemistry has widespread applications. Some of them are:

  • preparative organic synthesis of 1,4-substituted triazoles
  • modification of peptide function with triazoles
  • modification of natural products and pharmaceuticals
  • drug discovery
  • macrocyclizations using Cu(I) catalyzed triazole couplings
  • modification of DNA and nucleotides by triazole ligation
  • supramolecular chemistry: calixarenes, rotaxanes, and catenanes
  • dendrimer design
  • carbohydrate clusters and carbohydrate conjugation by Cu(1) catalyzed triazole ligation reactions
  • polymers
  • material science
  • nanotechnology, and
  • Bioconjugation, for example, azidocoumarin.

Click chemistry has also been used for selectively labeling biomolecules within biological systems. A Click reaction that is to be performed in a living system must meet an even more rigorous set of criteria than in an in vitro reaction. It must be bioorthogonal, meaning the reagents used may not interact with the biological system in any way, nor may they be toxic. The reaction must also occur at neutral pH and at or around body temperature. Most Click reactions have a high energy content. The reactions are irreversible and involve carbon-hetero atom bonding processes. An example is the Staudinger ligation of azides.

Read more about this topic:  Click Chemistry

Other articles related to "applications, application":

Photoresist Categories - Applications
... Microelectronics This application, mainly applied to silicon wafers/silicon integrated circuits is the most developed of the technologies and the most specialized in the field ...
Transistor - Comparison With Vacuum Tubes - Advantages
... that have allowed transistors to replace their vacuum tube predecessors in most applications are Small size and minimal weight, allowing the development of miniaturized electronic devices ... making transistors suitable for small, battery-powered applications ... period for cathode heaters required after power application ...
Biotechnology - Applications - Agriculture - Improved Taste, Texture or Appearance of Food
... The first genetically modified food product was a tomato which was transformed to delay its ripening ... Researchers in Indonesia, Malaysia, Thailand, Philippines and Vietnam are currently working on delayed-ripening papaya in collaboration with the University of Nottingham and Zeneca ...
Building On OpenStep
... The idea was to use OpenStep code as a basis for network-wide applications running across different platforms, as opposed to using CORBA or some other system ... Unlike OpenStep, which defined an operating system that applications would run in, under PDO the libraries were compiled into the application itself, creating a stand-alone "native" application for a ... of a considerable amount of supporting code (Objective-C and the libraries), PDO applications were nevertheless considerably smaller than similar CORBA solutions, typically about one-half to one-third the size ...
X Servers - Limitations and Criticism - Network
... (in a manner similar to GNU Screen in relation to terminals), and other applications and toolkits provide related facilities ... user interface (mouse, keyboard, monitor) of a running application to be switched from one location to another without stopping and restarting the ... This can be important in some applications, such as process monitoring and control ...