Cisapride

Cisapride is a gastroprokinetic agent, a drug which increases motility in the upper gastrointestinal tract. It acts directly as a serotonin 5-HT4 receptor agonist and indirectly as a parasympathomimetic. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system. It has been sold under the trade names Prepulsid (Janssen-Ortho) and Propulsid (in the U.S.). It was discovered by Janssen Pharmaceutica in 1980. In many countries, it has been either withdrawn from the market or had its indications limited because of side effects.

The commercial preparations of this drug are the racemic mixture of both enantiomers of the compound. The (+) enantiomer itself has the major pharmacologic effects and does not induce many of the detrimental side effects of the mixture.

Read more about Cisapride:  Clinical Uses, Veterinary Uses, Kinetics, Pharmacology and Mechanism of Action

Other articles related to "cisapride":

Cisapride - Pharmacology and Mechanism of Action
... As a prokinetic agent that increases gastrointestinal motility, cisapride acts as a selective serotonin agonist in the 5-HT 4 receptor subtype ... Cisapride also relieves constipation-like symptoms by indirectly stimulating the release of acetylcholine in the muscarinic receptors ...
Itopride - Adverse Drug Reactions - Cardiac Studies
... Itopride belongs to the same benzamide group as cisapride, a drug which was found to affect QT interval and possibly predispose those using it to cardiac arrhythmias ... This resulted in cisapride being voluntarily removed from the U.S ... An obvious concern due to similarities between cisapride and itopride led to several preclinical studies being undertaken to evaluate the cardiac safety profile of ...
Dyspepsia - Treatment
... of up to 50%, but the studies evaluated to come to this conclusion used the drug cisapride which has since been removed from the market (now only available as an ... potential benefit over placebo and another shows equivalence with cisapride ... This German-made phytopharmaceutical was found to be equivalent to cisapride and significantly superior to metoclopramide at reducing the symptoms of functional dyspepsia over a four week period ...
Hyperacidity - Treatment
... evaluated to come to this conclusion used the drug cisapride which has since been removed from the market (now only available as an investigational ... benefit over placebo and another shows equivalence with cisapride ... German-made phytopharmaceutical was found to be equivalent to cisapride and significantly superior to metoclopramide at reducing the symptoms of functional dyspepsia over a four-week period ...