Chorionic villus sampling (CVS), sometimes misspelled "chorionic villous sampling", is a form of prenatal diagnosis to determine chromosomal or genetic disorders in the fetus. It entails sampling of the chorionic villus (placental tissue) and testing it for chromosomal abnormalities, usually with FISH or PCR. CVS usually takes place at 10–12 weeks' gestation, earlier than amniocentesis or percutaneous umbilical cord blood sampling. It is the preferred technique before 15 weeks.
CVS was performed for the first time by Italian biologist Giuseppe Simoni, scientific director of Biocell Center, in 1983.
Use as early as 8 weeks in special circumstances has been described.
It can be performed in a transcervical or transabdominal manner.
Although this procedure is mostly associated with testing for Down Syndrome, overall, CVS can detect more than 200 disorders.
Other articles related to "chorionic villus sampling":
... CPM is diagnosed when some trisomic cells are detected on chorionic villus sampling and only normal cells are found on a subsequent prenatal test, such as ... is detected in approximately 1-2% of ongoing pregnancies that are studied by chorionic villus sampling (CVS) at 10 to 12 weeks of pregnancy ... Chorionic villus sampling is a prenatal procedure which involves a placental biopsy ...
14 weeks gestation, and usually up to about 20 weeks, and chorionic villus sampling, which can be done earlier (between 9.5 and 12.5 weeks gestation) but which may be slightly more ... One study comparing transabdominal chorionic villus sampling with second trimester amniocentesis found no signiﬁcant difference in the total pregnancy loss between the two procedures ... However, transcervical chorionic villus sampling carries a signiﬁcantly higher risk, compared with a second trimester amniocentesis, of total pregnancy loss (rel ...