Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. There are two different subtypes CCKA and CCKB which are ~50% homologous: Various cholecystokinin antagonists have been developed and are used in research, although the only drug of this class that has been widely marketed to date is the anti-ulcer drug proglumide.
|protein||gene||tissue distribution||preferred ligand||function|
|CCKA (CCK1)||CCKAR||primarily gastrointestinal tract, lesser amounts in the CNS||sulfated CCK >> nonsulfated CCK ≈ nonsulfated CCK||stimulation of bicarb secretion, gall bladder emptying and inhibiting gut motility|
|CCKB (CCK2)||CCKBR||primarily CNS, lesser amounts in the gastrointestinal tract||gastrin ≈ CCK (receptor does not descriminate between sulfated and nonsulfated peptides)||regulation of nociception, anxiety, memory and hunger|
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