Chiral Auxiliary

A chiral auxiliary is a chemical compound or unit that is temporarily incorporated into an organic synthesis in order to control the stereochemical outcome of the synthesis. The chirality present in the auxiliary can bias the stereoselectivity of one or more subsequent reactions. The auxiliary can then be cleaved from the substrate and is typically recovered for future use.

Most biological molecules and pharmaceutical targets exist as one of two possible enantiomers; consequently, chemical syntheses of natural products and pharmaceutical agents are frequently designed to obtain the target in enantiomerically pure form.

Read more about Chiral AuxiliaryAsymmetric Synthesis, 8-phenylmenthol, Oxazolidones, Chiral Auxiliaries in Industry

Other articles related to "chiral auxiliary, auxiliary, chiral":

Chiral Synthesis - Chiral Auxiliary
... One enantioinduction strategy is the use of a chiral auxiliary, which forms an adduct to the starting materials and physically blocks the other trajectory for attack, leaving only the desired trajectory open ... Assuming the chiral auxiliary is enantiopure, the different trajectories are not equivalent, but diastereomeric ... The auxiliary shares problems similar to protecting groups like protecting groups, auxiliaries require a reaction step to add and another to remove, increasing cost and ...
Chiral Auxiliary - Chiral Auxiliaries in Industry - Tipranavir
... addition of an organocuprate reagent to a chiral Michael acceptor ... The chiral oxazolidinone in the Michael acceptor controlled the stereochemistry of one of two stereocenters in the molecule ... The final, commercial route to Tipranavir does not feature a chiral auxiliary instead, this stereocenter is set by an asymmetric hydrogenation reaction ...