Chemokine - Receptors - Signal Transduction

Signal Transduction

Chemokine receptors associate with G-proteins to transmit cell signals following ligand binding. Activation of G proteins, by chemokine receptors, causes the subsequent activation of an enzyme known as phospholipase C (PLC). PLC cleaves a molecule called phosphatidylinositol (4,5)-bisphosphate (PIP2) into two second messenger molecules known as Inositol triphosphate (IP3) and diacylglycerol (DAG) that trigger intracellular signaling events; DAG activates another enzyme called protein kinase C (PKC), and IP3 triggers the release of calcium from intracellular stores. These events promote many signaling cascades (such as the MAP kinase pathway) that generate responses like chemotaxis, degranulation, release of superoxide anions and changes in the avidity of cell adhesion molecules called integrins within the cell harbouring the chemokine receptor.

Read more about this topic:  Chemokine, Receptors

Other articles related to "signal, signal transduction, signals":

10309 GeneCards SH2B2 Gene Gene Ontology Molecular function • signal transducer activity • SH3/SH2 adaptor activity • phospholipid binding • JAK pathway ... it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2 ...
... component • cytosol Biological process • small GTPase mediated signal transduction • Rho protein signal transduction • axon guidance • cell migration • regulation of small GTPase mediated signal ...
... apoptotic process • small GTPase mediated signal transduction • lamellipodium assembly • regulation of Rho protein signal transduction • intracellular signal transduction ... The encoded protein may form complex with G proteins and stimulate Rho-dependent signals ...
... apoptotic process • cytoskeleton organization • signal transduction • epidermal growth factor receptor signaling pathway • activation of adenylate ... The c-Raf protein functions in the MAPK/ERK signal transduction pathway as part of a protein kinase cascade ...

Famous quotes containing the word signal:

    The experience of a sense of guilt for wrong-doing is necessary for the development of self-control. The guilt feelings will later serve as a warning signal which the child can produce himself when an impulse to repeat the naughty act comes over him. When the child can produce his on warning signals, independent of the actual presence of the adult, he is on the way to developing a conscience.
    Selma H. Fraiberg (20th century)