|Molecular function||• glycoprotein binding
• receptor activity
• transmembrane signaling receptor activity
• scavenger receptor activity
• protein binding
|Cellular component||• plasma membrane
• integral to plasma membrane
• external side of plasma membrane
• fully spanning plasma membrane
|Biological process||• cell recognition
• cell proliferation
• T cell costimulation
|Sources: Amigo / QuickGO|
60.87 – 60.9 Mb
10.72 – 10.74 Mb
CD5 is a cluster of differentiation found on a subset of IgM-secreting B cells called B-1 cells, and also on T cells. B-1 cells have limited diversity of their B-cell receptor due to their lack of the enzyme terminal deoxynucleotidyl transferase (TdT) and are potentially self-reactive. CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli (such as bacterial proteins) and not by normal tissue proteins. CD5 was used as a T-cell marker until monoclonal antibodies against CD3 were developed.
In humans, the gene is located on the long arm of chromosome 11. There is no ligand confirmed, even if CD72, a C-type lectin, may be considered a probable ligand.
T cells express higher levels of CD5 than B cells. CD5 is upregulated on T cells upon strong activation. In the thymus, there is a correlation with CD5 expression and strength of the interaction of the T cell towards self-peptides.
Read more about CD5 (protein): Immunohistochemistry
Other articles related to "cd5":
... CD5is a good immunohistochemical marker for T-cells, although not as sensitive as CD3 ... T-cell neoplasms are reported to express CD5 and it is also found in chronic lymphocytic leukemia, hairy cell leukemia, and mantle cell lymphoma cells ... The absence of CD5in T cell acute lymphoblastic leukemia, while relatively rare, is associated with a poor prognosis ...