CD5 (protein)

CD5 (protein)

Identifiers Symbols CD5; LEU1; T1 External IDs OMIM: 153340 MGI: 88340 HomoloGene: 7260 GeneCards: CD5 Gene

Gene Ontology
Molecular function glycoprotein binding
receptor activity
transmembrane signaling receptor activity
scavenger receptor activity
protein binding
Cellular component plasma membrane
integral to plasma membrane
external side of plasma membrane
fully spanning plasma membrane
Biological process cell recognition
cell proliferation
T cell costimulation
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 921 12507 Ensembl ENSG00000110448 ENSMUSG00000024669 UniProt P06127 P13379 RefSeq (mRNA) NM_014207.3 NM_007650.3 RefSeq (protein) NP_055022.2 NP_031676.3 Location (UCSC) Chr 11:
60.87 – 60.9 Mb Chr 19:
10.72 – 10.74 Mb PubMed search

CD5 is a cluster of differentiation found on a subset of IgM-secreting B cells called B-1 cells, and also on T cells. B-1 cells have limited diversity of their B-cell receptor due to their lack of the enzyme terminal deoxynucleotidyl transferase (TdT) and are potentially self-reactive. CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli (such as bacterial proteins) and not by normal tissue proteins. CD5 was used as a T-cell marker until monoclonal antibodies against CD3 were developed.

In humans, the gene is located on the long arm of chromosome 11. There is no ligand confirmed, even if CD72, a C-type lectin, may be considered a probable ligand.

T cells express higher levels of CD5 than B cells. CD5 is upregulated on T cells upon strong activation. In the thymus, there is a correlation with CD5 expression and strength of the interaction of the T cell towards self-peptides.

Read more about CD5 (protein):  Immunohistochemistry

Other articles related to "cd5":

CD5 (protein) - Immunohistochemistry
... CD5is a good immunohistochemical marker for T-cells, although not as sensitive as CD3 ... T-cell neoplasms are reported to express CD5 and it is also found in chronic lymphocytic leukemia, hairy cell leukemia, and mantle cell lymphoma cells ... The absence of CD5in T cell acute lymphoblastic leukemia, while relatively rare, is associated with a poor prognosis ...