In immunology, the CD3 (cluster of differentiation 3) T-cell co-receptor is a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with a molecule known as the T-cell receptor (TCR) and the ζ-chain to generate an activation signal in T lymphocytes. The TCR, ζ-chain, and CD3 molecules together comprise the TCR complex.
Other articles related to "cd3":
... CD3is initially expressed in the cytoplasm of pro-thymocytes, the stem cells from which T-cells arise in the thymus ... and then into medullary thymocytes, and it is at this latter stage that CD3antigen begins to migrate to the cell membrane ... This high specificity, combined with the presence of CD3at all stages of T-cell development, makes it a useful immunohistochemical marker for T-cells in tissue ...