CBL (gene) - Homologues


Three mammalian homologues have been characterized, which all differ in their ability to function as adaptor proteins due to the differing lengths of their C-terminal UBA domains:

  1. c-Cbl: ubiquitously expressed, 906 amino acids in length.
  2. Cbl-b: ubiquitously expressed, 982 amino acids long in length.
  3. Cbl-c: lacks the UBA domain and is therefore only 474 amino acids in length. It is primarily expressed in epithelial cells however its function is poorly understood.

Interestingly, both c-Cbl and Cbl-b have orthologues in D. melanogaster (D-Cbl) and C. elegans (Sli-1), hinting at a long evolutionary path for these proteins.

Read more about this topic:  CBL (gene)

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