CBL (gene)

CBL (gene)

Identifiers Symbols CBL; C-CBL; CBL2; FRA11B; NSLL; RNF55 External IDs OMIM: 165360 MGI: 88279 HomoloGene: 3802 GeneCards: CBL Gene

Gene Ontology
Molecular function phosphotyrosine binding
sequence-specific DNA binding transcription factor activity
ubiquitin-protein ligase activity
signal transducer activity
calcium ion binding
protein binding
zinc ion binding
SH3 domain binding
ephrin receptor binding
Cellular component nucleus
plasma membrane
flotillin complex
Biological process regulation of transcription, DNA-dependent
cell surface receptor signaling pathway
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
positive regulation of phosphatidylinositol 3-kinase cascade
protein ubiquitination
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of apoptotic process
positive regulation of receptor-mediated endocytosis
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 867 12402 Ensembl ENSG00000110395 ENSMUSG00000034342 UniProt P22681 P22682 RefSeq (mRNA) NM_005188 NM_007619 RefSeq (protein) NP_005179 NP_031645 Location (UCSC) Chr 11:
119.08 – 119.18 Mb Chr 9:
44.15 – 44.23 Mb PubMed search

Cbl (named after Casitas B-lineage Lymphoma) is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ligase involved in cell signalling and protein ubiquitination. Mutations to this gene have been implication in a number of human cancers, particularly acute myeloid leukaemia.

Read more about CBL (gene):  Discovery, Structure, Homologues, Interactions

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CBL (gene) - Interactions
... Cbl gene has been shown to interact with Abl gene, ARHGEF7, C-Met, CD2AP, CSF1R ... CRK, CRKL, EGFR ...