Carcinogenesis - Mechanisms

Mechanisms

Cancer is a genetic disease: In order for cells to start dividing uncontrollably, genes that regulate cell growth must be damaged. Proto-oncogenes are genes that promote cell growth and mitosis, whereas tumor suppressor genes discourage cell growth, or temporarily halt cell division to carry out DNA repair. Typically, a series of several mutations to these genes is required before a normal cell transforms into a cancer cell. This concept is sometimes termed "oncoevolution." Mutations to these genes provide the signals for tumor cells to start dividing uncontrollably. But the uncontrolled cell division that characterizes cancer also requires that the dividing cell duplicates all its cellular components to create two daughter cells. The activation of anaerobic glycolysis (the Warburg effect), which is not necessarily induced by mutations in proto-oncogenes and tumor suppressor genes, provides most of the building blocks required to duplicate the cellular components of a dividing cell and, therefore, is also essential for carcinogenesis.

Read more about this topic:  Carcinogenesis

Other articles related to "mechanisms":

Lindley Darden - Research
... Darden has also worked on mechanisms, notably in her collaborative paper entitled "Thinking about Mechanisms" (2000), co-authored with Peter Machamer and Carl Craver ... her second book, entitled Reasoning in Biological Discoveries Essays on Mechanisms, Interfield Relations, and Anomaly Resolution ... In it, Darden propounds a number of strategies for discovering mechanisms in biology, including "Schema Instantiation," "Modular Subassembly," and "Forward/Backward ...
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AMM – Association For Machines And Mechanisms - Conferences and Workshops
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Surface Diffusion - Mechanisms - Cluster Diffusion
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