Cannabinoid Receptor Type 1 - Expression - Brain - Basal Ganglia

Basal Ganglia

CB1 receptors are expressed throughout the basal ganglia and have well established effects on movement in rodents. As in the hippocampus, these receptors inhibit the release of glutamate or GABA transmitter, resulting in decreased excitation or reduced inhibition based on the cell they are expressed in. Consistent with the variable expression of both excitatory glutamate and inhibitory GABA interneurons in both the basal ganglia's direct and indirect motor loops, synthetic cannabinoids are known to influence this system in a dose-dependent triphasic pattern. Decreased locomotor activity is seen at both higher and lower concentrations of applied cannabinoids, while an enhancement of movement may occur upon moderate dosages. However, these dose-dependent effects have been studied predominately in rodents and the physiological basis for this triphasic pattern warrants future research in humans. Effects may vary based on the site of cannabinoid application, input from higher cortical centers, and whether drug application is unilateral or bilateral.

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Other articles related to "basal ganglia":

Neuroanatomy Of Memory - Cortical Structures - Damage To The Cortex - Parkinson's Disease and Memory
... Parkinson's disease involves both damage to the basal ganglia and certain memory dysfunctions, suggesting that the basal ganglia are involved in specific types of memory ... This suggests that the basal ganglia work in both encoding and recalling spatial information ...
Spasmodic Torticollis - Pathophysiology
... Although no lesions are present in the basal ganglia in primary spasmodic torticollis, fMRI and PET studies have shown abnormalities of the basal ganglia and ... These neurotransmitters are secreted from the basal ganglia and travel to muscle groups in the neck ...
Lateral Globus Pallidus
... They go also to other elements of the basal ganglia system, the striatum, the substantia nigra pars reticulata, and the internal globus pallidus, where they release the ... does not work as an output base of the basal ganglia (not sending axons to the thalamus) but as the main regulator of the basal ganglia system ...
Basal Ganglia - History
... The acceptance that the basal ganglia system constitutes one major cerebral system took long to arise ... Vogt (1941) simplified the description of the basal ganglia by proposing the term striatum to describe the group of structures consisting of the caudate nucleus, the putamen ... pallidonigral ensemble, which represents the core of the basal ganglia ...