While the company eventually had several drugs in their pipeline focused on melanoma, colon cancer, lung cancer, solid tumors, and ophthalmic disease, their lead candidate Canvaxin was focused on melanoma. Canvaxin was a vaccine based treatment for melanoma, and was an immunotherapeutic. In the clinical trials it has been proven an effective treatment, with a significantly greater (P<0.0001) median survival rate over than no treatment. Immunotherapy in its most general form for cancer treatment uses the immune system to target tumor cells. While all cells produce cytokines and have receptor proteins on the cell surface, tumor cells may over-express them. Targeted immunotherapy towards these over expressed proteins could be an effective treatment towards different cancers. There are three types of immunotherapy, and they are briefly described below
-Passive Immunotherapy: Direct administration of monoclonal antibodies targeted to a specific cell receptor or protein to inhibit a tumor function or target the tumor itself.
-Non-Specific Active Immunotherapy: A general immune system response using cytokines and other cell signaling. Since this treatment is very general it has many complicated side effects.
-Specific Active Immunotherapy: The generation of cell-mediated and antibody immune responses focused on specific antigens expressed by the cancer cells. Canvaxin is an example of this therapy.
Read more about this topic: Cancer Vax
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Famous quotes containing the word products:
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