BCL2-like 1 (gene)

BCL2-like 1 (gene)

Identifiers Symbols BCL2L1; BCL-XL/S; BCL2L; BCLX; BCLXL; BCLXS; Bcl-X; PPP1R52; bcl-xL; bcl-xS External IDs OMIM: 600039 MGI: 88139 HomoloGene: 7639 ChEMBL: 4625 GeneCards: BCL2L1 Gene

Gene Ontology
Molecular function protein binding
protein kinase binding
identical protein binding
protein heterodimerization activity
BH3 domain binding
Cellular component cytoplasm
mitochondrial outer membrane
integral to membrane
nuclear membrane
Bcl-2 family protein complex
Biological process cytokinesis
ovarian follicle development
in utero embryonic development
release of cytochrome c from mitochondria
apoptotic process
germ cell development
cell proliferation
positive regulation of cell proliferation
male gonad development
apoptotic mitochondrial changes
negative regulation of autophagy
response to cytokine stimulus
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
innate immune response
response to cycloheximide
regulation of mitochondrial membrane permeability
regulation of mitochondrial membrane potential
cellular process regulating host cell cycle in response to virus
cellular response to amino acid stimulus
cellular response to alkaloid
cellular response to gamma radiation
mitotic cell cycle G2/M transition checkpoint
negative regulation of establishment of protein localization to plasma membrane
negative regulation of release of cytochrome c from mitochondria
negative regulation of anoikis
negative regulation of intrinsic apoptotic signaling pathway
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 598 12048 Ensembl ENSG00000171552 ENSMUSG00000007659 UniProt Q07817 Q64373 RefSeq (mRNA) NM_001191 NM_009743 RefSeq (protein) NP_001182 NP_033873 Location (UCSC) Chr 20:
30.25 – 30.31 Mb Chr 2:
152.78 – 152.83 Mb PubMed search

Bcl-2-like protein 1 is a protein that in humans is encoded by the BCL2L1 gene.

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species(ROS) and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.

Read more about BCL2-like 1 (gene):  Interactions

Other articles related to "gene":

BCL2-like 1 (gene) - Interactions
... BCL2-like1 (gene has been shown to interact with RAD9A, RTN1, BAK1, Reticulon 4, Bcl-2-associated X protein, BCAP31, Bcl-2-interacting killer, PPP1CA, Noxa, VDAC1, BCL2L11, Bcl-2-associated death promoter, Bcl-2 ...