Aryl Hydrocarbon Receptor Nuclear Translocator

Aryl Hydrocarbon Receptor Nuclear Translocator

Identifiers Symbols ARNT; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; TANGO; bHLHe2 External IDs OMIM: 126110 MGI: 88071 HomoloGene: 1261 ChEMBL: 5618 GeneCards: ARNT Gene

Gene Ontology
Molecular function sequence-specific DNA binding transcription factor activity
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
transcription coactivator activity
aryl hydrocarbon receptor activity
protein binding
transcription factor binding
aryl hydrocarbon receptor binding
sequence-specific DNA binding
protein heterodimerization activity
Cellular component nucleus
nucleoplasm
transcription factor complex
cytoplasm
Biological process response to hypoxia
embryonic placenta development
positive regulation of endothelial cell proliferation
transcription, DNA-dependent
positive regulation vascular endothelial growth factor production
cell differentiation
positive regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of protein sumoylation
cellular response to stress
mRNA transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
positive regulation of erythrocyte differentiation
positive regulation of glycolysis
positive regulation of transcription, DNA-dependent
positive regulation of transcription from RNA polymerase II promoter
positive regulation of hormone biosynthetic process
regulation of transcription from RNA polymerase II promoter in response to hypoxia
cellular response to hypoxia
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 405 11863 Ensembl ENSG00000143437 ENSMUSG00000015522 UniProt P27540 P53762 RefSeq (mRNA) NM_001197325.1 NM_001037737.2 RefSeq (protein) NP_001184254.1 NP_001032826.1 Location (UCSC) Chr 1:
150.78 – 150.85 Mb Chr 3:
95.43 – 95.5 Mb PubMed search

The ARNT gene encodes the aryl hydrocarbon receptor nuclear translocator protein that forms a complex with ligand-bound aryl hydrocarbon receptor (AhR), and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene.

The aryl hydrocarbon receptor (AhR) is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the aryl hydrocarbon receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound AhR to xenobiotic responsive elements in the promoters of genes for these enzymes.

Read more about Aryl Hydrocarbon Receptor Nuclear Translocator:  Interactions

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Aryl Hydrocarbon Receptor Nuclear Translocator - Interactions
... Aryl hydrocarbon receptor nuclear translocator has been shown to interact with HIF1A, SRC-1, AIP, SIM1, Aryl hydrocarbon receptor, EPAS1, SIM2 and ...

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