Antimicrobial Peptides - Immunomodulation

Immunomodulation

In addition to killing bacteria directly they have been demonstrated to have a number of immunomodulatory functions that may be involved in the clearance of infection, including the ability to alter host gene expression, act as chemokines and/or induce chemokine production, inhibiting lipopolysaccharide induced pro-inflammatory cytokine production, promoting wound healing, and modulating the responses of dendritic cells and cells of the adaptive immune response. Animal models indicate that host defence peptides are crucial for both prevention and clearance of infection. It appears as though many peptides initially isolated as and termed "antimicrobial peptides" have been shown to have more significant alternative functions in vivo (e.g. hepcidin).

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Other articles related to "immunomodulation":

Atherosclerosis - Research
... Immunomodulation of atherosclerosis is the term for techniques that modulate immune system function to suppress this macrophage action ... Immunomodulation has been pursued with considerable success in both mice and rabbits since about 2002 ... The immunomodulation approaches mentioned above, because they deal with innate responses of the host to promote atherosclerosis, have far greater prospects for success ...