Ankylosing Spondylitis

Ankylosing spondylitis (AS, from Greek ankylos, crooked; spondylos, vertebrae), previously known as Bekhterev's disease, Bekhterev syndrome, and Marie-Strümpell disease, is a chronic inflammatory disease of the axial skeleton with variable involvement of peripheral joints and nonarticular structures. AS is a form of spondyloarthritis, a chronic, inflammatory arthritis where immune mechanisms are thought to have a key role. It mainly affects joints in the spine and the sacroiliac joint in the pelvis, and can cause eventual fusion of the spine.

It is a member of the group of the spondyloarthropathies with a strong genetic predisposition. Complete fusion results in a complete rigidity of the spine, a condition known as "bamboo spine". As of 2012, no cure is known for AS, although treatments and medications are available to reduce symptoms and pain.

Read more about Ankylosing Spondylitis:  History, Epidemiology, Pathophysiology, Signs and Symptoms, Diagnosis, Treatment, Prognosis, Notable People With Ankylosing Spondylitis

Other articles related to "ankylosing spondylitis, spondylitis, ankylosing":

Linkage Disequilibrium - Example: Human Leukocyte Antigen (HLA) Alleles
... Association of ankylosing spondylitis with HLA-B27 allele Ankylosing spondylitis Total Patients Healthy controls HLA alleles Total 2x2 association table of patients and ... Table 3 shows association of HLA-B27 with ankylosing spondylitis among a Dutch population ... allele Relative risk (%) FAD (%) FAP (%) Ankylosing spondylitis B27 8. 0.89 Reiter's syndrome B27 8. 0.67 Spondylitis in inflammatory bowel disease B27 10 50 ...
Spondylitis Association Of America
... The Spondylitis Association of America (SAA) started in 1983 as a charity by people affected by ankylosing spondylitis, a crippling, debilitating form of spinal arthritis that often strikes ... SAA's mission is to be a leader in the quest to cure ankylosing and related diseases, and to empower those affected to live life to the fullest ... Her goal was to get word out about ankylosing spondylitis and help support others with this disease ...
Notable People With Ankylosing Spondylitis
... John Addey, an English astrologer who lived from 1920 to 1982 ... Mike Atherton, a broadcaster, journalist and retired England international cricketer born in 1968 ...
BASDAI - Related Tests
... Other tests include the Bath Ankylosing Spondylitis Functional Index (BASFI) a test reflecting functional limitations in patients with more advanced disease, Ankylosing Spondylitis Disease ...
HLA-B - Related Conditions
... Ankylosing spondylitis A version of the HLA-B gene called HLA-B27 increases the risk of developing ankylosing spondylitis ... Although most patients with ankylosing spondylitis have the HLA-B27 variation, many people with this particular variation never develop the disorder ... Other genetic and environmental factors are likely to affect the chances of developing ankylosing spondylitis and influence its progression ...