Androgen Insensitivity Syndrome

Androgen insensitivity syndrome (AIS) is a condition that results in the partial or complete inability of the cell to respond to androgens. The unresponsiveness of the cell to the presence of androgenic hormones can impair or prevent the masculinization of male genitalia in the developing fetus, as well as the development of male secondary sexual characteristics at puberty, but does not significantly impair female genital or sexual development. As such, the insensitivity to androgens is clinically significant only when it occurs in genetic males (i.e. individuals with a Y-chromosome, or more specifically, an SRY gene). Clinical phenotypes in these individuals range from a normal male habitus with mild spermatogenic defect or reduced secondary terminal hair, to a full female habitus, despite the presence of a Y-chromosome.

AIS is divided into three categories that are differentiated by the degree of genital masculinization: complete androgen insensitivity syndrome (CAIS) is indicated when the external genitalia are that of a normal female; mild androgen insensitivity syndrome (MAIS) is indicated when the external genitalia are that of a normal male, and partial androgen insensitivity syndrome (PAIS) is indicated when the external genitalia are partially, but not fully, masculinized.

Androgen insensitivity syndrome is the largest single entity that leads to 46,XY undermasculinized genitalia.

Read more about Androgen Insensitivity Syndrome:  Signs and Symptoms, Genetics, Diagnosis, Management, Epidemiology, History

Other articles related to "androgen insensitivity syndrome, syndrome, androgens, androgen insensitivity, androgen, insensitivity":

Androgen Insensitivity Syndrome - History - Popular Culture
... English "The Ring" series) describes that the central antagonist Sadako as having this syndrome ...
Intersex - Conditions and Scope - Causes - Conditions
... XY Androgen insensitivity syndrome (AIS) People with AIS have a Y chromosome, (typically XY), but are unable to metabolize androgens in varying degrees ... and genitalia are said to have complete androgen insensitivity syndrome (CAIS) ... In mild and partial androgen insensitivity syndrome (MAIS and PAIS), the body is partially receptive to androgens, so there is virilization to varying degrees ...
Partial Androgen Insensitivity Syndrome - Signs and Symptoms
... Partial androgen insensitivity syndrome is diagnosed when the degree of androgen insensitivity in an individual with a 46,XY karyotype is great enough to partially ... This includes any phenotype resulting from androgen insensitivity where the genitalia is partially, but not completely masculinized ... during the embryonic stage of development, testes form in an androgen-independent process that occurs due to the influence of the SRY gene on the Y chromosome ...
Partial Androgen Insensitivity Syndrome
... Partial androgen insensitivity syndrome (PAIS) is a condition that results in the partial inability of the cell to respond to androgens ... As such, the insensitivity to androgens is only clinically significant when it occurs in genetic males (i.e ... PAIS is one of three types of androgen insensitivity syndrome, which is divided into three categories that are differentiated by the degree of genital ...
Disorders Of Sex Development - Conditions
... 48, XXXX (also known as tetrasomy X, quadruple X, and XXXX syndrome) - A condition that describes a female with two extra female chromosomes ... It is considered a variation of Triple X syndrome. 48, XXYY (also known as XXYY syndrome) - A condition that describes a male with one extra female chromosome and one extra male chromosome ...

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