Ampicillin/sulbactam

Ampicillin/sulbactam is a combination of the common penicillin-derived antibiotic ampicillin and sulbactam, an inhibitor of bacterial beta-lactamase. Two different forms of the drug exist. The first, developed in 1987 and marketed in the United States under the tradename Unasyn, is an intravenous antibiotic. The second, an oral form called sultamicillin, is marketed under the trade name Ampictam outside of the United States. Ampicillin/sulbactam is used to treat infections caused by bacteria resistant to beta-lactam antibiotics. Sulbactam blocks the enzyme which breaks down ampicillin and thereby allows ampicillin to attack and kill the bacteria.

Skeletal formula of ampicillin Skeletal formula of sulbactam Skeletal formula of sultamicillin, highlighting ampicillin in blue and sulbactam in orange

Ampicillin/sulbactam is also used when the cause of an infection is not known (empiric therapy). Intra-abdominal infections, skin infections, pneumonia, and gynecologic infections. It is active against a wide range of bacterial groups, including Staphylococcus aureus, Enterobacteriaceae, and anaerobic bacteria. Importantly, it is not active against Pseudomonas aeruginosa and should not be used alone when infection with this organism is suspected or known.

Read more about Ampicillin/sulbactam:  Synonyms

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... Cefazaflur (INN) is a first-generation cephalosporin antibiotic ... Antibacterials cell envelope antibiotics (J01C-J01D) Intracellular inhibit peptidoglycan subunit synthesis and transport NAM synthesis inhibition (Fosfomycin) DADAL/AR inhibitors (Cycloserine) bactoprenol inhibitors (Bacitracin) Glycopeptide inhibit PG chain elongation Vancomycin# (Oritavancin Telavancin) Teicoplanin (Dalbavancin) Ramoplanin β-lactams/ (inhibit PBP cross-links) Penicillins (penams) Extended sp aminopenicillins Amoxicillin# Ampicillin# (Pivampicillin Hetacillin Bacampicillin Metampicillin Talampicillin) Epicillin carboxypenicillins Carbenicillin (Carindacillin) Ticarcillin Temocillin ureidopenicillins Azlocillin Piperacillin Mezlocillin other Mecillinam (Pivmecillinam) Sulbenicillin Narrow sp β-lactamase sensitive Benzylpenicillin (G)# Clometocillin Benzathine benzylpenicillin# Procaine benzylpenicillin# Azidocillin Penamecillin Phenoxymethylpenicillin (V)# Propicillin Benzathine phenoxymethylpenicillin Pheneticillin β-lactamase resistant Cloxacillin# (Dicloxacillin Flucloxacillin) Oxacillin Meticillin Nafcillin Penems Faropenem Carbapenems Biapenem Ertapenem antipseudomonal (Doripenem Imipenem Meropenem) Panipenem Cephalosporins/Cephamycins (cephems) 1st (PEcK) Cefazolin# Cefacetrile Cefadroxil Cefalexin Cefaloglycin Cefalonium Cefaloridine Cefalotin Cefapirin Cefatrizine Cefazedone Cefazaflur Cefradine Cefroxadine Ceftezole 2nd (HEN) Cefaclor Cefamandole Cefminox Cefonicid Ceforanide Cefotiam Cefprozil Cefbuperazone Cefuroxime Cefuzonam cephamycin (Cefoxitin Cefotetan Cefmetazole) carbacephem (Loracarbef) 3rd Cefixime# Ceftriaxone# antipseudomonal (Ceftazidime# Cefoperazone) Cefcapene Cefdaloxime Cefdinir Cefditoren Cefetamet Cefmenoxime Cefodizime Cefotaxime Cefpimizole Cefpiramide Cefpodoxime Cefsulodin Cefteram Ceftibuten Ceftiolene Ceftizoxime oxacephem (Flomoxef Latamoxef ‡) 4th (antips-) Cefepime Cefozopran Cefpirome Cefquinome 5th Ceftobiprole Ceftaroline fosamil Veterinary Ceftiofur Cefquinome Cefovecin Monobactams Aztreonam Tigemonam Carumonam Nocardicin A β-lactamase inh penam (Sulbactam Tazobactam) clavam (Clavulanic acid) Combinations Amoxicillin/clavulanic acid# Imipenem/cilastatin# Ampicillin/flucloxacillin Ampicillin/sulbactam (Sultamicillin) Piperacillin/tazobactam Other polymyxins/detergent (Colistin Polymyxin B) depolarizing (Daptomycin) hydrolyze NAM-NAG (Lysozyme) Gramicidin #WHO-EM ‡Withdrawn from market Clinical trials †Phase III §Never to phase III M BAC bact (clas) gr+f/gr+a (t)/gr-p (c)/gr-o drug (J1p, w, n, m, vacc) ...

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... Ampicillin has been used extensively to treat bacterial infections since 1961 ... Until the introduction of ampicillin by the British company Beecham, penicillin therapies had only been effective against Gram-positive organisms such as staphylococci and streptococci ...

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