Allelic Exclusion

Allelic exclusion is a process by which only one allele of a gene is expressed while the other allele is silenced. For most genes, the individual inherits one copy of each gene from each parent.

At least two distinct selection events can lead to allelic exclusion. On one hand, one allele of the gene can be transcriptionally silent, which would result in the expression of only the second allele. On the other hand, both alleles can be transcribed, in which case posttrancriptional and posttranslational mechanisms will lead to the elimination of the protein product of one allele.

Though the mechanism by which allelic exclusion occurs is not fully understood.

Read more about Allelic ExclusionAllelic Exclusion in B-Lymphocytes, Allelic Exclusion in Sensory Neurons

Other articles related to "allelic exclusion, exclusion":

Allelic Exclusion in Sensory Neurons
... A recent study showed that CpA-methylation helps for allelic exclusion in sensory neurons. ...
Harald Von Boehmer - Publications (Selected Papers)
... Exclusion and inclusion of alpha and beta T cell receptor alleles ... Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus ... feedback on TCRbeta rearrangement as essential mechanism for TCRbeta allelic exclusion ...

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