An integral component of the Mannich reaction, in addition to an amine and a carbonyl compound, is a carbanion, which plays the role of the nucleophile in the nucleophilic addition to the ion formed by the reaction of the amine and the carbonyl.
The Mannich reaction can proceed both intermolecularly and intramolecularly:
... The Mannich-Reaction is employed in the organic synthesis of natural compounds such as peptides, nucleotides, antibiotics, and alkaloids (e.g ... The Mannich reaction is also used in the synthesis of medicinal compounds e.g ... rolitetracycline (Mannich base of tetracycline), fluoxetine (antidepressant), tramadol, and tolmetin (anti-inflammatory drug) ...
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