Identifiers Symbols ALDH1A2; RALDH(II); RALDH2; RALDH2-T External IDs OMIM: 603687 MGI: 107928 HomoloGene: 68368 GeneCards: ALDH1A2 Gene EC number

Gene Ontology
Molecular function retinal dehydrogenase activity
3-chloroallyl aldehyde dehydrogenase activity
retinal binding
Cellular component nucleus
Biological process blood vessel development
kidney development
liver development
regulation of endothelial cell proliferation
heart morphogenesis
vitamin A metabolic process
midgut development
positive regulation of cell proliferation
negative regulation of cell proliferation
determination of bilateral symmetry
anterior/posterior pattern specification
proximal/distal pattern formation
positive regulation of gene expression
neural crest cell development
morphogenesis of embryonic epithelium
neural tube development
pituitary gland development
neuron differentiation
lung development
hindbrain development
pancreas development
embryonic camera-type eye development
response to estradiol stimulus
response to vitamin A
response to cytokine stimulus
embryonic forelimb morphogenesis
ureter maturation
retinol metabolic process
retinoic acid metabolic process
retinal metabolic process
9-cis-retinoic acid biosynthetic process
positive regulation of apoptotic process
retinoic acid receptor signaling pathway
embryonic digestive tract development
face development
cellular response to retinoic acid
Sources: Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8854 19378 Ensembl ENSG00000128918 ENSMUSG00000013584 UniProt O94788 Q62148 RefSeq (mRNA) NM_001206897 NM_009022 RefSeq (protein) NP_001193826 NP_033048 Location (UCSC) Chr 15:
58.25 – 58.79 Mb Chr 9:
71.22 – 71.3 Mb PubMed search

Retinaldehyde dehydrogenase 2 (RALDH2) is an enzyme that in humans is encoded by the ALDH1A2 gene.

This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a paracrine hormone signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels that facilitate posterior organ development and prevent spina bifida. Three transcript variants encoding distinct isoforms have been identified for this gene.