Alcohol and Cancer - Possible Mechanisms of Alcohol As A Carcinogen - Acetaldehyde

Acetaldehyde

Acetaldehyde is produced by the liver as it breaks down ethanol. The liver then normally eliminates 99% of the acetaldehyde. An average liver can process 7 grams of ethanol per hour. For example, it takes 12 hours to eliminate the ethanol in a bottle of wine, giving 12 hours or more of acetaldehyde exposure. A study of 818 heavy drinkers found that those who are exposed to more acetaldehyde than normal through a defect in the gene for alcohol dehydrogenase are at greater risk of developing cancers of the upper gastrointestinal tract and liver.

Read more about this topic:  Alcohol And Cancer, Possible Mechanisms of Alcohol As A Carcinogen

Other articles related to "acetaldehyde":

Acetaldehyde - Safety - Carcinogenicity - Colon Cancer
... We also know that most of the acetaldehyde produced in the large intestine is generated from bacterial oxidation of ethanol ... In experiments with animals, microbially mediated ethanol oxidation results were high acetaldehyde concentrations in the colon after alcohol administration ...
Indole-3-acetaldehyde Oxidase
... In enzymology, an indole-3-acetaldehyde oxidase (EC 1.2.3.7) is an enzyme that catalyzes the chemical reaction (indol-3-yl)acetaldehyde + H2O + O2 (indol-3-yl)acetate + H2O2 The 3 substrates of this ...
Threonine Aldolase
... aldolase (EC 4.1.2.5) is an enzyme that catalyzes the chemical reaction L-threonine glycine + acetaldehyde Hence, this enzyme has one substrate, L-threonine, and two products, glycine and ... name of this enzyme class is L-threonine acetaldehyde-lyase (glycine-forming) ... This enzyme is also called L-threonine acetaldehyde-lyase ...
Lactate Aldolase
... is an enzyme that catalyzes the chemical reaction (S)-lactate formate + acetaldehyde Hence, this enzyme has one substrate, (S)-lactate, and two products, formate ... The systematic name of this enzyme class is (S)-lactate acetaldehyde-lyase (formate-forming) ... Other names in common use include lactate synthase, and (S)-lactate acetaldehyde-lyase ...
Alcohol And Cancer - Possible Mechanisms of Alcohol As A Carcinogen - Acetaldehyde
... Acetaldehyde is produced by the liver as it breaks down ethanol ... The liver then normally eliminates 99% of the acetaldehyde ... the ethanol in a bottle of wine, giving 12 hours or more of acetaldehyde exposure ...